[4][5] After compiling a perfect 15-0 record, Ramírez beat Johnny Garcia by unanimous decision on December 5, 2015 to win the vacant WBC Continental Americas light welterweight title.
[7] On March 17, 2018, Ramírez defeated Amir Imam by unanimous decision with scores of 120-108, 117-111 and 115-113 to win the vacant WBC super lightweight title.
[8] In his next fight, Ramírez faced Antonio Orozco, then #3 by the WBC at light welterweight, at the Save Mart Center in Fresno, California.
[12] On July 27, 2019, Ramírez fought undefeated WBO light welterweight champion Maurice Hooker in a unification fight.
[15] On October 30, 2021, it was revealed that Ramírez would face the former two-weight world champion José Pedraza on February 5, 2022, in the main event of an ESPN broadcast Top Rank card.
[17] Ramírez was scheduled to face Rances Barthelemy on April 27, 2024 at Save Mart Center in Fresno, CA.
[20] On November 16, 2024, Ramirez faced Arnold Barboza Jr. in a ten-round bout at The Venue Riyadh in Saudi Arabia.
Following his loss to Arnold Barboza Jr., talks emerged of Ramírez being included in a high-profile boxing card featuring Devin Haney and Ryan Garcia.