José Francisco "El Nene" Sanfilippo (born 4 May 1935) is a former Argentine footballer who played as a striker.

During his club career he played for San Lorenzo, Boca Juniors and Banfield in Argentina, Nacional in Uruguay, and Bangu and SC Bahia in Brazil.

[3] Sanfilippo joined Uruguayan side Nacional in 1964, after the first round of the Copa Libertadores.

[5] At international level, Sanfilippo played for the Argentina national football team in the 1958 FIFA World Cup and the 1962 FIFA World Cup.

[6] He is the joint ninth-highest goalscorer for the Argentina national football team, alongside Leopoldo Luque, with 22 goals.