José Santos Guardiola Bustillo (1 November 1816 – 11 January 1862) was a two-term President of Honduras.

His good relations with the British helped facilitate the return of governance of the Bay Islands and the La Mosquitia region into Honduras.

He struck a deal with Queen Victoria on which Great Britain recognized the Honduran sovereignty of the aforementioned territories (the treaty of Wyke-Cruz) as long as the inhabitants of the islands were granted freedom of worship.

[3] The next day, on 11 January 1862, President Guardiola was sleeping with his wife in the presidential palace of Honduras.

The provisional president, José María Medina, ordered a court to hear the case and the suspects were sentenced to death.