His father was Vicente de la Cuadra y Vayas and his mother was Ana Victoria Vargas y Jiménez.

De la Cuadra was part of the "Guayaquil Group" and wrote many essays, novels, articles and above all, short stories.

The "Guayaquil Group" was one of the most recognized literary groups in Ecuador in 1930-1940, which also included the writers Enrique Gil Gilbert, Demetrio Aguilera Malta, Joaquín Gallegos Lara and Alfredo Pareja Diezcanseco.

[4] Some of his works have been filmed by Ecuadorian directors and translated into several languages, including La Tigra and Los Sangurimas.

He died in Guayaquil on February 27, 1941 of a massive brain hemorrhage at the age of 37 This article about an Ecuadorian writer or poet is a stub.