Joséphine de Meaux was born in Boulogne-Billancourt, Hauts-de-Seine, France.

[citation needed] She studied at the French National Academy of Dramatic Arts from 1999 to 2002, acting in several plays under the direction of professionals.

She made her on-screen debut in 2003, with the movie Who Killed Bambi?, directed by Gilles Marchand.

In 2019, she released her first motion picture as a director, a comedy titles Les petits flocons.

She's well known for playing in comedy like Those Happy Days, Tellement proches and The Intouchables, all three directed by Éric Toledano and Olivier Nakache but also Vilaine, Case départ and more recently L'Élève Ducobu.