He also serves as the current Secretary of the Department of Human Settlements and Urban Development since July 29, 2022.

He is one of the Filipino billionaires despite not being included in Forbes magazine's 50 richest people in the Philippines in 2020.

He worked as a contractor in the 1980s before establishing the real estate firm New San Jose Builders, Inc. (NSJBI) in 1986.

[5] He is also known for the development of the Las Casas Filipinas de Acuzar in Bataan, a resort known for its Spanish colonial-era buildings transplanted from elsewhere.

[6][7] On July 29, 2022, Acuzar was appointed as secretary of the Department of Human Settlements and Urban Development by President Bongbong Marcos.