[1] She is interested in the fauna of Venezuela, in particular the Guayana Region where table-top mountains called tepuis provide habitats for endemic plant and animal species: some amphibians are known only from a single tepuy.

From a geological point of view, the tepuis have been isolated for approximately 120 million years,[2] and it has been suggested that the tepuy habitats are a "lost world" that could support relictual populations.

[3] However, Señaris's work suggests that in a zoological context tepuis are not as isolated as originally believed, and that some of their species are neoendemics rather than paleoendemics.

For example, an endemic group of tree frogs, Tepuihyla, have diverged after the tepuis were formed, that is, speciation followed colonization from the lowlands.

[5] In recognition of her "contributions to the knowledge of centrolenid diversity and morphology" she has had a genus of glass frog, Celsiella, named after her nickname which is Celsi.