Joseph-Marie Trịnh Như Khuê (11 December 1898 – 27 November 1978) was the first Vietnamese cardinal of the Catholic Church.

Khuê was born in Tràng Duệ, Bình Lục, Hà Nam and ordained to the priesthood on 1 April 1932.

On 18 April 1950, he was appointed Apostolic Vicar of Hanoi and Titular Bishop of Synaus by Pope Pius XII.

Khuê received his episcopal consecration on the following 15 August from Bishop Thaddeus Lê Hữu Từ, OCist, with Bishops Francisco Gomez de Santiago, OP, and Peter Phạm Ngọc Chi serving as co-consecrators, in the Cathedral of Hanoi.

[1] The archbishop was reserved as a cardinal in pectore by Pope Paul VI when the consistory was announced on April 28, 1976, and was published and created Cardinal Priest of S. Francesco di Paola ai Monti[2] at the consistory on 24 May of that same year.