At the federal level, Republican Edward Brooke was elected to the United States Senate over Democrat Endicott Peabody and Democrats won seven of twelve seats in the United States House of Representatives.

Former Speaker of the House Joseph W. Martin Jr. was the only incumbent not re-elected, after his defeat in the Republican primary against Margaret Heckler.

Republican Francis W. Sargent was elected Lieutenant Governor over Democrat Joseph E. McGuire.

Kevin White Democratic Kevin White Democratic Incumbent Secretary of the Commonwealth Kevin White, defeated Republican Raymond Trudel, Socialist Labor candidate Willy N. Hogseth, and Prohibition candidate F. Oliver Drake in the general election.

In the general election, Buczko defeated Republican John J. Buckley, Socialist Labor candidate August Johnson, and Prohibition candidate Roger I. Williams in the general election.