He later lived in the High Desert Southern California city of Palmdale, briefly in Las Vegas, Nevada, and then Hattiesburg, Mississippi.

The following year, he released Sell Your Dope and relocated to Hattiesburg, Mississippi,[4] where he met drummer Jody Stallone, keyboardist/bassist Darrell Havard, and producer Tim Ramenofsky (a.k.a.

Ramenofsky produced and released Afroman's album Because I Got High in 2000 on T-Bones Records; it was distributed primarily through local concerts and the file-sharing service Napster before its title track was played on The Howard Stern Show.

[4] In late 2001, the song became a hit and was featured in the 2000s films Jay and Silent Bob Strike Back, The Perfect Score, and Disturbia.

[6] After the single's success, Afroman joined the lineup of Cypress Hill's fall festival "Smoke Out" with the Deftones, Method Man, and others.

[4] Afroman started releasing his music independently and mostly through the Internet in 2004,[4] and that year, he recorded Jobe Bells, which satirized traditional Christmas songs.

[9] In October 2014, Afroman released a remix of his hit song "Because I Got High" in order to highlight the usefulness of cannabis as part of the effort to legalize its sale across the United States.

[11] In January 2023, he released an hour-long video on YouTube titled "How To Be Happy In An Unhappy World - Sermon By Afroman" detailing his experiences and understanding on life's issues and how to overcome tribulations through faith in the word of God.

[13][14] In August 2022, the Adams County, Ohio Sheriff's Department searched Afroman's home on suspicion of kidnapping and drug trafficking.

[16] He also posted about a previous burglary on his home where he was threatened with arrest by the sheriff's department if he kept checking about the progress of the case and was told they did not have time to provide him with an update.

[15] He recorded a trio of songs criticizing the raid, titled "Will You Help Me Repair My Door", “Lemon Pound Cake" (also the name of his album, set to the tune of Under the Boardwalk by The Drifters) and "Why You Disconnecting My Video Camera", and released three music videos composed primarily of security camera recordings of the raid, to his YouTube account, on December 29, 2022.