As a teenager, Flores worked for the United States Navy government in Guam as a messenger, and an operator at the Naval cable station.

[3] The South of the Market Tribune turned a good profit until the Great Depression and a printing worker's strike forced it out of business.

[4][7] His nomination followed the resignations of Richard Barrett Lowe and the subsequent acting governor Marcellus Boss.

[7] During his governorship, Flores pushed for Guamanian self-governance and a Delegate from Guam to the United States,[4] and opened public health centers in various locations.

[3] After leaving office, Flores founded a number of companies, including the Guam Savings and Loan Association in 1954, now named BankPacific and run by his grandson Phillip Flores, Mariannas Finance Corporation, Pacific American Insurance Company, and Guam Air Lines, and owned a number of office buildings and apartment buildings.