Joseph Clifford (Cliff) McIsaac, (August 30, 1930 – July 25, 2006) was a politician, public servant and veterinarian.
He was appointed by Premier Ross Thatcher as Minister of Municipal Affairs from 1965 until 1971 and then as Minister of Education in the provincial cabinet from 1967 until the government's defeat in the 1971 provincial election.
During the 30th Canadian Parliament, he sat in the federal Liberal caucus, led by Prime Minister Pierre Trudeau, serving as a parliamentary secretary and then Government Whip.
His riding was abolished, replaced by The Battlefords—Meadow Lake, and he was defeated in the 1979 and 1980 federal elections.
After leaving politics, McIsaac served as a commissioner of the Canadian Dairy Commission and chair of the National Farm Products Marketing Council.