The Joseph Mitchell House is a historic residence in southern Monroe County, Indiana, United States.

Located on Ketcham Road west of the community of Smithville,[1] it is one of the oldest houses in Monroe County, and it has been designated a historic site.

In 1823, Kentucky resident Joseph Mitchell was awarded a land grant in present-day Monroe County in return for his service in the War of 1812.

Toward the south, there are no windows and only a single doorway, which allows access to the basement; the plain gabled wall appears once to have been hidden by a porch that was removed due to structural deterioration.

[1] As the third-oldest house in Monroe County, it was deemed significant primarily because of its architecture,[2]: 3  despite the presence of alterations such as the removal of the original porch.