Joseph Vincent McKee, Sr. (August 8, 1889 – January 28, 1956) was a teacher at DeWitt Clinton High School in the Bronx, New York, who later became a politically active Democrat and briefly served as the acting mayor of New York City.

In 1926, he was elected president of the New York City Board of Aldermen on the ticket with James J. Walker for mayor.

Walker, who resigned amid scandal and the threat of a criminal indictment, subsequently fled to Europe until the danger of prosecution appeared remote.

McKee, who was sometimes mockingly referred to as "Holy Joe", running as a write-in candidate, lost a special election to John P. O'Brien in November 1932 to fill out the rest of Walker's unexpired term as mayor.

In November 1933, McKee ran for mayor as the Recovery Party candidate against Democratic Mayor John P. O'Brien and Republican-City Fusion Party candidate Fiorello La Guardia, but lost to La Guardia.