Joseph H. Vann (11 February 1798 – 23 October 1844) was a Cherokee leader of mixed-race ancestry, a businessman and planter in Georgia, Tennessee and Indian Territory.

Joseph and his sister Mary were children of James Vann and Nannie Brown, both Cherokee of mixed-blood, with partial European ancestry.

[1] James Vann had tried to plan to have Joseph to inherit his wealth, but Cherokee law stipulated that the home go to his wife Peggy, while his possessions and property were to be divided among his children.

Eventually the Cherokee Council granted Joseph the inheritance in line with his father's wish; this included 2,000 acres (8.1 km2) of land, trading posts, river ferries, and the Vann House in Spring Place, Georgia.

In 1842, 20–25 slaves of Joseph Vann, Lewis Ross, and other wealthy Cherokee at Webbers Falls revolted and fled with guns and horses in an attempt to escape from Indian Territory to Mexico.

Vann put his surviving slaves to work as crew members of his steamboat, named Lucy Walker after his favorite race horse.