He played in Major League Baseball (MLB) for the Los Angeles Dodgers, Philadelphia Phillies, Texas Rangers, Oakland Athletics, Pittsburgh Pirates, and Milwaukee Brewers and in the KBO League for the Lotte Giants and Doosan Bears.

He made 14 appearances for the Lookouts, including 11 starts and had a record of 3–5 and an ERA of 4.71 when he was promoted to the AAA Albuquerque Isotopes.

He made his Major League debut in relief on June 1, 2011, against the Colorado Rockies, allowing two hits in a scoreless seventh inning during a 3–0 Dodgers loss.

On July 31, 2012, Lindblom was traded to the Philadelphia Phillies along with prospect Ethan Martin for outfielder Shane Victorino.

The Texas Rangers acquired Lindblom and minor league pitching prospect Lisalverto Bonilla on December 9, 2012, from the Philadelphia Phillies in exchange for Michael Young.

[13] Lindblom was called up on May 20 when Derek Lowe was designated for assignment and optioned back to the Triple-A Round Rock Express on May 21.

On December 16, 2016, Lindblom signed a minor league contract with the Pittsburgh Pirates that included an invitation to spring training.

[21] On December 11, 2017, the Doosan Bears announced the signing of Lindblom to a one-year, $1.45 million contract.

2018 was a successful season for Lindblom; he started 26 games with a 15–4 record, a league-leading 2.88 ERA, and the Pitcher's Golden Glove award.

Lindblom received the 2019 KBO League Most Valuable Player Award, after posting a 20–3 record with a 2.50 ERA and 189 strikeouts over 194+2⁄3 innings.

[23] On December 16, 2019, Lindblom signed a three-year contract worth $9.125 million with the Milwaukee Brewers.

[29] As a reliever, Lindblom relies chiefly on four-seam and two-seam fastballs around 91 mph and a high-80s cutter, although he also mixed in a curveball, a slider, and a changeup.