He played for the Louisville Colonels, Washington Senators, New York Giants, Boston Beaneaters, and Pittsburgh Pirates.

He immediately had the best season of his career, teaming up with Rusie to provide the ultimate 1-2 pitching staff of the era.

Meekin pitched 418 innings and compiled a record of 33–9 to lead the National League in winning percentage.

[1] Meekin also hit three triples in a game that season, on July 4; this set a record for pitchers that has never been equaled.

[6] After the 1894 regular season, New York faced the first place Baltimore Orioles in the Temple Cup series.

Baltimore is considered by some to be the greatest baseball team of the 19th century,[7] but Meekin and Rusie won two games each to sweep the Orioles in four straight.

In one game in 1896, Meekin threw the first intentional walk in baseball history, to slugger Jimmy Ryan.