At the Treasury Department he was in charge of customs, internal revenue and reorganized the War Risk Insurance division until November 15, 1920, when he resigned "in order to adjust his personal affairs."

He opposed the nomination of Franklin D. Roosevelt as the Democratic Party's candidate for president and along with John J. Raskob supported the candidacy of Alfred E.

[2] In early 1930s Shouse divorced his wife of twenty-one years and married the wealthy divorcee, Catherine Filene Dodd.

Shouse broke with the liberals and became the president of the American Liberty League, 1934–40, a new conservative organization formed by leading businessmen to oppose parts of the New Deal.

"[5] Shouse said that he had "deep sympathy" with the goals of the NRA, explaining, "While I feel very strongly that the prohibition of child labor, the maintenance of a minimum wage and the limitation of the hours of work belong under our form of government in the realm of the affairs of the different states, yet I am entirely willing to agree that in the case of an overwhelming national emergency the Federal Government for a limited period should be permitted to assume jurisdiction of them.

Shouse grew up in Kentucky, where Thoroughbred horse breeding and racing was an integral part of daily life as well as the state's economy.

Shouse and his second wife Catherine owned Wolf Trap Farm in Vienna, Virginia, where they raised and bred boxer dogs as well as Thoroughbred horses used as show hunters and for competing in flat racing.