Santos-Knox was signed by the Winnipeg Blue Bombers after driving nine hours with his father to a tryout camp which his father had found in Charlotte, North Carolina.

[2] He started his rookie season on special teams but by the end of the regular season was a starting linebacker and was being praised by coach Mike O'Shea and media for big plays at big moments of games.

[3] After recording 10 tackles and 3 sacks against Toronto on July 27, 2018, Santos-Knox was named the CFL's third star of the week.

After the CFL canceled the 2020 season due to the COVID-19 pandemic, he chose to opt-out of his contract with the Edmonton Eskimos on August 27, 2020.

[5] On February 6, 2021, it was announced that Santos-Knox had signed with the Hamilton Tiger-Cats.