[4] Holmes attended the University of Texas, where she played for the Longhorns women's basketball team, In her freshman season, she averaged 12.1 points, 8.2 rebounds and 1.9 assists per game.

[5] In her Sophomore season, she averaged 6.8 points, 6.0 rebounds and 1.4 assists per game.

[8][9] On April 17, 2020, the Seattle Storm selected Holmes as the 19th pick in the second round of the 2020 WNBA draft.

[11] Holmes helped the United States under-17 team win a gold medal at the 2014 FIBA U-17 World Championship, She averaged 10.6 points, 5.7 rebounds and 1 assist per game.

[12] She also won a silver medal at the 2017 FIBA Under-19 Women's Basketball World Cup with the United States under-19 team, and she averaged 9 points, 8.7 rebounds and 1.9 assists per game.