[2][3] In November 2021, following the resignation of Věslav Michalik, Síkela became the new candidate of the Mayors and Independents (STAN) political party for the post of Czech Minister of Industry and Trade in the emerging government of Petr Fiala (a coalition of SPOLU and PirSTAN).

This included the Community Energy Act, which enabled the sharing of surplus self-generated electricity from renewable sources,[7] and was awarded the Business Law of the Year prize in 2024.

[9] His ministerial tenure also saw the Czech Republic move away from dependence on Russian gas imports, partially via the acquisition of a share in the LNG terminal in Eemshaven, Netherlands, in cooperation with the ČEZ Group, which Sikela announced in July 2022.

[15] Following the 2024 European elections, Síkela was nominated by the Czech government to this role, to serve under President Ursula von der Leyen.

[18] He is also involved in shaping the Global Gateway strategy, which promotes international cooperation aimed at fostering sustainable growth in Europe and in partner countries.