Jozefina Çoba Topalli graduated from Luigj Gurakuqi University in Shkodra with a double major in mathematics and law.

In September 2005, in her speech at the oath-taking ceremony as Speaker of the Albanian Assembly, Jozefina Çoba Topalli underlined her steady determination to be an advocate of the opposition, too.

[citation needed] In the framework of parliamentary diplomacy, a novelty the Speaker of the Albanian Parliament brought into Albanian political life, Jozefina Topalli was engaged in the acceleration of the ratification by the EU states parliaments of the Stabilisation and Association Agreement between Albania and the EU, as well as the NATO protocols for the accession of Albania into the North Atlantic alliance.

[citation needed] For her valuable contribution in politics, Topalli was awarded the "Medal of Honor" by the Chairman of the Legislative Assembly of St. Petersburg, Vadim Tulapanov.

[citation needed] In April 2012, the Čair Municipality in the Republic of North Macedonia accorded the title "Honorary Citizen" for Ms.