Napout served as President of CONMEBOL from August 2014 until his resignation on 11 December 2015 after his arrest in Zurich, Switzerland, in relation to the 2015 FIFA corruption case.

[4][5] On 11 December 2015 Napout resigned as President of CONMEBOL and was succeeded in interim capacity by Wilmar Valdez.

[6] After his arrest Napout agreed to extradition and appeared before a federal judge in New York on 15 December 2015 and declared himself not guilty on the five charges brought against him.

[11] In November 2017, investigations of the Paradise Papers revealed that, in 2010, Napout created a company in the Bahamas the day he started to receive bribes from the Datisa (the consortium handling football broadcasting rights in Paraguay).

[15][16] Agustín Moya portrayed Napout in the 2020 Amazon Prime Video original series El Presidente.