Juan Claros Pérez de Guzmán y Fernández de Córdoba, 11th Duke of Medina Sidonia (1642–1713) was a Spanish noble who became Duke of Medina Sidonia in 1667 upon the death of his half-brother Gaspar Juan Pérez de Guzmán, 10th Duke of Medina Sidonia.
In 1668 he married Antonia Teresa Pimentel (1646–1677), daughter of the 8th Duke of Benavente.
They had one son: The Duke married for a second time in 1678 to Mariana Sinforosa de Guzmán y Guevara, 4th Duchess of Medina de las Torres, whose father, Ramiro Núñez de Guzmán, had been Viceroy of Naples.
During the reign of Charles II, he was viceroy of Catalonia between 1690 and 1693, which he had to defend against French troops and Catalan rebels during the Nine Years' War.
When Felipe V came to the throne in 1701, he was replaced by the Marquis of Villafranca and was made Caballerizo mayor, a post he would hold until his death.