Juan Francisco Fresno Larraín (26 July 1914 – 14 October 2004) was a Chilean cardinal of the Roman Catholic Church.

He was born in Santiago de Chile as the son of Luis Alfredo Fresno Ingunza y Elena Larraín Hurtado.

He was educated at the seminary of Santiago de Chile and later at the Pontifical Gregorian University, Rome where he earned a licentiate in theology.

This in turn led to the 1988 Chilean national plebiscite that marked the beginning of the end of the military regime.

Pope John Paul II named him Archbishop of Santiago de Chile on 3 May 1983.