Pizzuti was born in the Barracas neighbourhood of Buenos Aires and joined the Banfield youth team at the age of 14.

He became the top scorer in the Argentine league in 1949, this brought him to the attention of several major clubs and he eventually signed for River Plate in 1951.

In 1952, after only one season with River, Pizzuti left to join Racing Club de Avellaneda, he became the topscorer in the Argentine league for a second time in 1953.

He retired as a player in 1963, by the end of his career he had scored a total of 182 goals in 349 games, to make him one of the top 20 all time goalscorers in the Argentine league.

Pizzuti played for Argentina between 1951 and 1959, he was part of the squad for the South American Championship in 1959 where he scored three goals to help them to win the title.