Jufré accompanied Pedro de Villagra when he returned to fight in the civil war in Peru against Gonzalo Pizarro in 1547 and 1548.

After the death of Valdivia in Tucapel (1553), he aided the population in the south with food; in 1554 he crushed a rebellion of the Promaucaes in Gualemo on the Lontué River (now the province of Curicó).

Returning in 1562 because of the new Mapuche revolt, he became lieutenant of Governor of Chile and organized aid for the war in the south.

In the Cabildo of Santiago (the municipal city council) Jufré held various positions, such as alcalde (magistrate) and regidor in the decades between 1550 and 1570.

He planted the first vineyards in his encomienda of Macul near Santiago where he made wine that he sold in Peru along with other goods.