Leguizamón previously played for the Jaguares, the Argentine side which made its debut in Super Rugby for the 2016 season.

He also played for the London Irish (2005–06, 2007–08) in England, and for Stade Français (2008–09, 2010–11) as well as Lyon OU (2011–15) in the Top 14 and Pro D2 leagues of France.

[citation needed] Leguizamón played 87 tests for Argentina from 2005 to 2019, including four Rugby World Cups and also captaining the team three times in his career.

[citation needed] Leguizamón made his debut with Los Pumas in April 2005 in a match against Japan, won 68 to 36 in Buenos Aires.

On October 9, 2019, he played his last test for the Argentina national team, a 47–17 win over the United States.