[1] He moved to Peru in the early 1540s, and became a supporter of Gonzalo Pizarro, taking part on his side in the civil wars.
At the end of the civil war Captain Núñez de Prado returned to the city of Chuquisaca in Upper Peru.
[2] After receiving La Gasca's instructions for his mission, Núñez de Prado raised money from his property and from some of his friends.
Núñez de Prado travelled through the valleys of Tupiza, Jujuy and Chicoana to reach his new territory and to find a site for its capital.
[3] Aguirre initiated a vigorous and aggressive policy towards the Indians, allocating them to his followers as forced laborers to work on their landholdings.
The colonists were greatly outnumbered, and in 1553 had to retreat beyond the Dulce River to a location a few leagues away, where they founded Santiago del Estero.
In the case of El Barco, Valdivia, with the voluntarily help of Francisco de Aguirre, meant to arbitrarily extend his Chilean jurisdiction to the southeast of his assigned territory.