During all this time, Sauvage exerted a strong influence on the education of the young prince and future Emperor Charles V. At his inauguration as monarch of Castile in 1517, the young Charles arrived in Valladolid with his Flemish courtiers, among whom Grand chancellor Le Sauvage stood out.
Upon their arrival, the mistrust of the Castilian elite awaited them, fearful that the government of the Court would come in the hands of foreigners.
When the Cortes of Valladolid was opened on 2 February 1518, Charles appointed Jean le Sauvage as its president.
Finally, Charles was forced to give in to the protests, replacing Sauvage with Spanish Bishop Pedro Ruiz de la Mota.
A few months later, in June 1518, during Charles's stay in Zaragoza, Sauvage died from the plague that was raging in the Kingdom at the same time.