[2] He was first able to enter Cusco on 3 November 1545, and was finally consecrated as bishop on October 24, 1546, by his fellow Dominican friar, Jerónimo de Loayza, the newly elevated Archbishop of Lima.

Because of his loyalty to the king, Solano roused the ire of the rebel Francisco de Carvajal, who commented that he, "having sat in his church and prayed for peace among Christians, walked around the camp like a field marshal".

He was present at the Battle of Jaquijahuana, which decisively ended the uprising in favor of the royalist Viceroyalty of Peru.

He obtained money from the Spanish conquistadores from the booty they had gained in their victory with the purpose of relieving the suffering of the native population, with which he built the Hospital de San Lázaro.

[5] Solano returned to Spain in October 1560, seeking support in his efforts to curb the behavior of the conquerors as well as the division of his diocese, which he considered too large for a single bishop.

The college would later be transformed into the Pontifical University of Saint Thomas Aquinas, commonly called the Angelicum.