Fra' Juan de Homedes y Coscón (c. 1477 – 6 September 1553) was a Spanish knight of Aragon who served as the 47th Grand Master of the Order of Malta, between 1536 and 1553.

[1] He was buried in the crypt of the Chapel of St Anne in Fort Saint Angelo but his remains were later moved to St. John's Co-Cathedral in Valletta.

[2] De Homedes is portrayed in an unflattering light in Dorothy Dunnett's 1966 novel The Disorderly Knights, which is set in 1551 during the Dragut Raid on Malta and Gozo and the subsequent fall of Tripoli.

Eight Pointed Cross depicts the loss of Gozo and Tripoli to Dragut Raïs and Sinan Pasha, and the Order's failure to help the over five thousand civilians captured in the sieges.

De Homedes appears in The Course of Fortune by Tony Rothman (J. Bolyston, 2015), in which his role in the first siege of Malta (1551), the sack of Gozo (1551) and his prosecution of the knights after the fall of Tripoli are described in detail.