During his government, Lieutenant Antonio de Latorre founded 43 pueblos, in which 41,000 persons were settled.
On 21 April he left Cartagena to take up his new position in Santafé de Bogotá, the capital of the viceroyalty.
He was already old and infirm, although he had recently married a 17-year-old Cartagena native, María de Salas.
His predecessor, Manuel Antonio Flórez, a popular viceroy who had served more than 11 years in the office, had apparently been forced to resign by José de Gálvez, Minister of the Indies in Spain, and Antonio Caballero y Góngora, Archbishop of Bogotá.
A sealed royal document intended to beopened only in the event of his death identified Archbishop Caballero y Góngora as his replacement.