Juana Enríquez was the Regent of Navarre during the absence of her husband in the Navarrese Civil War (1451–1455); she also served as Governor of Catalonia in 1462 in the place of her son (who was his father's nominal governor) and, finally, as Regent of Aragon during the absence of her husband in the Catalan Civil War between 1465 and 1468.

[1] Juana Enriquez was a daughter of Fadrique Enríquez and Mariana Fernández de Córdoba, 4th Lady of Casarrubios del Monte, and succeeded her mother in 1431.

Such breaking of the law of succession led to a confrontation with the Crown of Aragon and a conflict between farmers and nobles, the outbreak of Navarrese Civil War.

[4] Accused of having ordered the poisoning of Charles of Viana, Juana fled to Girona, seeking the protection of the bishop.

Juana Enríquez was appointed regent of Aragon in March 1465, when her husband was absent in Catalonia, trying to suppress the rebellion.

[5] Queen Juana's greatest wish was to have her son, Ferdinand, married to Isabella, half-sister and heir presumptive of King Henry IV of Castile.