[2] In 1952, the hospital began its service with 4 rooms, 20 beds, 2 retired part-time doctors and 2 nurses of the Holy Cross Congregation.

[4] Nursing school commenced in 1966 and the hospital was recognized by the Medical Council of India (MCI) in 1971 for internship training of doctors.

The campus has facilities including libraries, reading rooms, museums, stadium, gym, table tennis hall and a chapel.

Other amenities include ATMs, police outpost, post office, a branch of the South Indian Bank, various restaurants, cafes and a supermarket.

The hospital includes the following departments:[11][12] Jubilee Hrudhayalaya is a fully integrated cardiovascular centre providing multidimensional care.

It is the largest exclusive cardiac centre in the state of Kerala, having 300 dedicated cardiac beds and 80 critical care beds [13] The Charles Pinto Centre provides comprehensive care for patients with congenital clefts of the lip, palate and complex facial clefts.

The centre has partnered with Smile Train, a charitable organisation based in New York, USA, that helps with funding for treatment of cleft patients.

Courses run currently are: Other PG Medical Courses: The institute runs the IDCCM (Indian Diploma in Critical Care Medicine) programme, making it one of only two medical colleges in the state providing super specialty training in Critical Care Medicine.

Courses offered include: Nursing [27][28] Allied Health Professions [29] Student life revolves around various aspects in the college, including:[30] JUBICON is the annual national medical students' conference held at Jubilee Mission Medical College and Research Institute.