Her mother, Jean Silverside, was a television actress, and her father, Sefton Myers, was a successful property developer who also managed artists and singers—most notably Andrew Lloyd Webber and Tim Rice during the writing of Jesus Christ Superstar.

Under the name Tzuke & Paxo, they eventually secured a recording contract and the duo released a single, "These are the Laws", produced by Tony Visconti.

[2] Tzuke's career as a solo artist began in 1977, when she signed to Elton John's label The Rocket Record Company.

Tzuke completed a 57 date tour of the UK, culminating as the headline act at that year's Glastonbury Festival.

Several performances from the tour were recorded and released at the end of 1982 as a double album, Road Noise: The Official Bootleg.

In March 1985, "I'll Be the One" was issued as a new single from Tzuke's forthcoming sixth album, The Cat Is Out, which was mainly recorded at her home studio and released in June 1985.

She began working on her seventh album, though took some time off in June 1987 when she gave birth to her first daughter, Bailey.

[2] Two singles from the album, "Wonderland" and "Fly", were performed on the BBC1 lunchtime programme Pebble Mill at One in November 1992.

Tzuke released her tenth studio album, Under the Angels, in October 1996 on her own label, Big Moon Records.

In 1998, Tzuke released her eleventh studio album, Secret Agent, again on her own label, Big Moon.

Two dates in March 2004 were played at London's Cabot Hall in Canary Wharf as part of the Docklands Music Festival and the following night at Dartford's Mick Jagger Centre.

It was accompanied by a tour, with her daughter Bailey Tzuke on backing vocals, and collaborations with other musicians such as Gareth Gates on piano.

In 2010, Tzuke released a thirty-year celebratory double-album titled Moon On a Mirrorball, via a new deal with Wrasse Records.

Wrasse also re-released all of Tzuke's Big Moon back catalogue as downloads, and reissued her debut album Welcome to the Cruise on CD.

A live album, October Road, was recorded from the tour and was released in March 2011 via Tzuke's official website.

In 2018, Tzuke joined with Beverley Craven and Julia Fordham to record "Safe", a song that she had written with Beth Nielsen Chapman, whilst on a Chris Difford songwriting retreat.