[1] After being discovered for her first role at the age of 14, Godrèche left school and moved away from her parents to begin her acting career.

[10] Her early work included commercial modeling for a Japanese chocolate maker, as well as a teen magazine.

Godrèche was nominated for a 2002 César Award for Best Supporting Actress for her performance in the surprise European hit, L'Auberge espagnole.

[18] In 2004, she began a relationship with actor and director Maurice Barthélemy, who is the father of her daughter, Tess, born 19 April 2005.

[19] Godrèche has considered formally converting to Judaism as an adult, which she attributed to her close relationship with her paternal grandparents.

[1] In February 2024, Godrèche filed police complaints against Jacques Doillon and Benoît Jacquot for sexual assault committed in the 1980s when she was a minor.

[20][21][22][23] At the 49th César Awards on 23 February 2024, Godrèche gave a speech on sexual violence and addressed France's omertà around #MeToo.

It was screened during the opening ceremony of the festival's Un Certain Regard section and free to the public on 15 May as part of the Cinéma de la Plage program.