She was most active in London and Oxford, where she designed a variety of schools, university buildings and public housing projects.

She was one of six children born to Willem Ledeboer, who worked as a banker, and Harmina Engelbertha van Heek.

She studied alongside Jessica Albery, Justin Blanco White, and Mary Crowley (later Medd), and they developed a commitment to housing reform and social concerns which impacted their future careers.

She designed a neighbourhood unit in Hemel Hempstead in 1950–1955, comprising houses, flats, maisonettes and shops.

[3] Ledeboer was described by Lynne Walker in the Oxford Dictionary of National Biography as "one of the most significant voices in post-war housing policy".