The organization works to increase communication between women and connect the public with forms of women-based media.

In 1994, she won more than two thirds of the ballots cast in the general election against the Republican candidate, Fernando G. Cantu Jr. (1944–2016), 71,029 (68.5 percent to 32,624 (31.5 %).

In 2013, Zaffirini will push for the issuance of tuition revenue bonds to fund capital construction projects on state college and university campuses, including TAMIU in Laredo.

[16] In 2012, Lieutenant Governor Dewhurst removed Zaffirini from the chairmanship of the Senate Committee on Higher Education in favor of Kel Seliger, a Republican from Amarillo.

Zaffirini said that she will continue to influence higher education policy "but the only difference is that the gavel won't be in my hand.

"[17] In July 2013, Zaffirini joined her Democratic colleagues in voting against Republican-sponsored legislation which passed the Senate, 19 to 11, to reduce from twenty-six to twenty weeks of gestation the maximum time limit during which a woman can procure an abortion.

Strongly opposed by business and athletic interests, the measure is now pending before the Texas House of Representatives.

[1] In July 2013, Zaffirini was twice sued in Bexar County for alleged "gross mismanagement" of an estate valued at $150 million.

The second suit alleges that Zaffirini and two co-defendants, David H. Arredondo and Clarissa N. Chapa, committed tax fraud, forged documents, and paid themselves excessive fees in the amount of $420,000 for management of the Alexander holdings.

In return, Zaffirini will take control of nearly 450 acres of undeveloped real estate off Del Mar Boulevard.

[26] On the occasion of Republican presidential candidate Donald Trump's visit to Laredo on July 23, 2015, Zaffrini wrote the lead column on the editorial page the next day in the Laredo Morning Times to question Trump's commitment to border issues.