[6][7] She first received acclaim in the 1970s as a muralist her artistic practice shifted over time and now is centered on works-on-paper, principally pastels, which frequently incorporate indigenist imagery and the social-political tension of gender roles.

The artists were criticized in Artweek magazine by reviewer Shifra Goldman for "shedding … their cultural identity and political militance" in order to "enter the mainstream as competitive professionals.

Included in the exhibition were sixteen Chicano artists (of which were three women) and this event brought international significance to Hernández's work.

La Vida Sobre Papel, opened in January 2011 and included several new series of work, one of which was the noted serial murders of women in Ciudad Juárez.

According to the Chicago Weekly, "The only thing as conspicuous as the artist's skill is her message: being human is hard, a woman harder, and life as a Latina occasionally downright grisly.

"The station at the edge of the continent" features 24 mosaic glass panels designed by Hernández positioned over its two-passenger platforms.

In 2018, the importance of her status as an American artist was confirmed when the Pulitzer Prize winning Chief Art Critic of the Los Angeles, Christopher Knight, reviewed her solo exhibition at MOLAA and wrote "...Hernández’s art is churned by her marvelous color sense, which unmoors any illustrative limits of the genre.

In 2019, her newest mural commission marks the return of her artistic presence to the historic district of downtown Los Angeles when her seven-story mural "La Nueva Reina de Los Angeles" is installed on the northwest residential tower of La Plaza Village at Broadway and the Hollywood Freeway.

[2] Judithe Hernández's artwork is characterized by several key themes and artistic techniques that are deeply intertwined with her social and political activism.

[21] Through her unique visual language and unwavering commitment to social justice, she has made significant contributions to the Chicano art movement and continues to inspire generations of artists and activists.

[25][better source needed] She served as an artist in residence in 2011 at the University of Chicago, in the Center for the Study of Race, Politics, and Culture.