Later credits include Mildred Layton in the 1984 ITV television series The Jewel in the Crown, for which she received her first BAFTA award nomination; Lady Catherine de Bourgh in the 1980 television serial version of Pride and Prejudice; Vera Donovan in the 1995 film adaptation of Stephen King's Dolores Claiborne; and as Maria Thins in the 2003 film Girl with a Pearl Earring, for which she earned another BAFTA award nomination for Best Supporting Actress.

Two of her most notable past roles are Mildred Layton in The Jewel in the Crown (1984; for which she received her first BAFTA nomination) and Lady Catherine de Bourgh in the 1980 TV serial version of Pride and Prejudice.

In 1995, she portrayed Kathy Bates' domineering former employer in Dolores Claiborne, who is dying in present-time, but is seen as a vibrant, glowing woman in flashback sequences.

At Christmas 2011, she appeared in a small role similar to that which she portrayed in Little Dorrit as Aunt Chastity along with Una Stubbs and Phyllida Law in The Bleak Old Shop of Stuff.

[8] In 2012, she began appearing in the BBC TV series Call the Midwife as Sister Monica Joan, an elderly nun in early stages of dementia.

[7][10] Parfitt has also recently appeared in BBC's spy tale, The Game; a film, Hello Carter; a Radio 4 show, Tom Wrigglesworth's Hang-Ups; and Jessica Hynes's suffragette sitcom Up the Women.