[4] In the early 1990s, Reyes began her television career with guest starring roles in a number of shows, including Law & Order, NYPD Blue, and The Sopranos.

She has starred in a number of made for television movies, primarily for Lifetime network, including Little Girl Lost: The Delimar Vera Story (2008), and The Pregnancy Project (2012).

After leaving Scrubs, Reyes guest-starred in several shows, including Castle, Medium, Off the Map, and Law & Order: Special Victims Unit.

In 2011, she starred as a mother dealing with her estranged husband's return into her life after his stint in prison in the independent drama Gun Hill Road.

[5] Reyes also had small supporting roles in several films, including Went to Coney Island on a Mission from God... Be Back by Five (1998), Bringing Out the Dead (1999), Washington Heights (2002), and Dirty (2005).

[9] Two weeks following the show's cancellation, Reyes was cast opposite Niecy Nash in the TNT crime comedy-drama Claws playing the role of Annalise "Quiet Ann" Zayas.

She played the role of Eva, executive producer of media conglomerate Waystar Royco's ATN news channel, in the HBO drama series Succession in 2018.

[16] Reyes appeared as the mother of the lead character in the romantic drama film, Turtles All the Way Down based on the 2017 novel of the same name by John Green.