The book is autobiographical, and it focuses on Canseco's days as a major leaguer, his marriages, his daughter, and off-field incidents including his barroom brawl in 2001.

The book deals primarily with anabolic steroids, drawing upon the personal experiences of Canseco.

He takes personal credit for introducing steroids to baseball and names former teammates Mark McGwire, Juan González, Rafael Palmeiro, Iván Rodríguez, and Jason Giambi as fellow steroid users.

He also believes he was blackballed by baseball when Bud Selig decided that the league needed to be cleaned up.

One of Juiced's central precepts is that steroid use is not in and of itself a bad thing, as long as the person is being monitored by a physician and the dosages are small.