He has previously played in the National Hockey League (NHL) for the Edmonton Oilers, Chicago Blackhawks and Minnesota Wild.

Khaira was selected 63rd overall by the Edmonton Oilers in the 2012 NHL Entry Draft after his second season in the British Columbia Hockey League (BCHL) with the Prince George Spruce Kings.

[1] At the completion of his freshman season in 2012–13 with the Huskies, Khaira left college to pursue a major junior career closer to home in the Western Hockey League (WHL) with the Everett Silvertips.

[4][5] This made Khaira only the third player of Punjabi Indian descent to play in the NHL, after Robin Bawa and Manny Malhotra.

[15] On September 6, 2024, Khaira signed a one-year, American Hockey League contract with the Syracuse Crunch.