Domínguez was born in the Buenos Aires Province town of Chacabuco, located in the heart of the Pampas and the Argentine maize belt.

[3] Domínguez entered public service in 1989 as head of the board of advisors of the Buenos Aires Province Social Security Institute.

He was influential in the governor's 2001 decision to rescind the province's water service concession granted several years earlier to Azurix, a local Enron subsidiary.

[8] Pending, however, were improvements in strained relations between the center-left administration of President Cristina Kirchner and (among others) nation's important agrarian sector, whose leading figures approved of her decision to reinstate the Agriculture Ministry,[9] but expressed skepticism at the appointment to the post of a legislator with no farming experience, and who had recently supported a hike in provincial farm income taxes.

[3] The contentious entity regulating agricultural subsidies, ONCCA, was dissolved in 2011;[11] and the proposed return to a Federal Grain Board (such as the one prevailing in Argentina between 1935 and the creation of ONCCA in 1996),[12] as well as the revival of the Federal Agrarian Council of provincial officials dealing with the sector, succeeded in dividing the powerful agrarian lobby round table, the Mesa de Enlace.