Marciari-Alexander began her career at the Yale Center for British Art, where she was curator of paintings and sculpture and later an associate director of the museum.
As director, she has overseen the completion of a seven-year endowment campaign as well as the renovation of the Hackerman House, which holds the museum's collection of Asian art.
[1][2] As part of a Théodore Rousseau Fellowship offered by the Metropolitan Museum of Art,[1] she studied abroad at New York University in Paris and London[2][6] and obtained a master's degree in French literature in 1992.
[2] She then moved to New Haven, Connecticut to attend Yale University and earned a master's degree and PhD in art history in 1993 and 1999, respectively.
[17] In 2021, Marciari-Alexander and her administration became the subjects of controversy[18] after several employees fell ill from toxic vapors related to on-site museum construction.
[22][23] In 2022, mayor of Baltimore Brandon Scott sent Marciari-Alexander a letter requesting that she allow the employees to hold an independent union election.
[25][26] In 2018, one of their children, then in the eighth grade, spoke to Yahoo Lifestyle about living with psoriatic arthritis and speaking at the United Nations on behalf of an organization, NCD Child, which focuses on the rights of youth with or at risk of non-communicable diseases.