Born in Melbourne, Khazzouh moved to Sydney as a child and attended Oakhill College in the suburb of Castle Hill.

He was poised to move to the United States in early 2006 but an offer from the Razorbacks convinced him to stay in Australia and he joined the team as a full-time player for the first time in 2006–07.

[6] After finishing second in the NBL Rookie of the Year voting behind Joe Ingles in 2007,[7] Khazzouh had a very productive season for the Razorbacks in 2007–08 as he averaged 11.1 points and 6.2 rebounds in 28 games.

On 28 July 2009, Khazzouh signed a one-year deal with Ironi Ramat Gan of the Israeli Basketball Super League.

Despite playing for the last place NBL club in 2010–11, Khazzouh was a hot favourite for the MVP award, though ultimately he finished second in the voting behind Wollongong's Gary Ervin.

In December 2011, halfway through the 2011–12 NBL season, Khazzouh was invited to the Golden State Warriors NBA pre-season camp.

After a stint with the Los Angeles Lakers summer league team in July 2012, Kazzouh joined Asseco Prokom Gdynia of Poland for the 2012–13 season.

[15] On 21 December 2015, he was ruled out for the rest of the season after scans revealed he required surgery to repair a ruptured right quadriceps tendon.

[21] Khazzouh featured in the 2005 film Star Wars: Episode III – Revenge of the Sith, playing a wookiee named Lachichuk.