Reister qualified for his first ATP World Tour tournament at Basel where he lost in the first round to Guillermo García-López 6–7(4), 2–6.

He defeated 27th seed Feliciano López in the first round 6–1, 7–6(5), 6–2 to record his first ever ATP World Tour victory.

He then lost to Xavier Malisse 7–6(7), 4–6, 1–6, 4–6 Reister was given a wildcard into the ATP 500 2010 International German Open.

Reister won his first challenger title in Monza defeating Alessio Di Mauro in the final.

Reister became only the second man in the history of professional tennis to record a golden set (first had been Bill Scanlon in 1983, Stefano Napolitano joined them in 2015).