Her first career break came in 2006 when she replaced an indisposed Pamela Armstrong as Fiordiligi in Mozart's Così fan tutte at the New York City Opera.
[1] She also received positive reviews in 2007 for her performance of Fiora in L'amore dei tre re with the Opera Orchestra of New York at Carnegie Hall and for her portrayal of Leonora in Giuseppe Verdi's Il trovatore at the Caramoor International Music Festival.
In December 2010 she performed the world premiere of Thomas Pasatieri's Bel Canto Songs for the George London Foundation Recital Series at the Morgan Library.
[9][10] In 2012 Di Giacomo made her first appearance with the Los Angeles Opera as Donna Anna to Ildebrando D'Arcangelo's Don Giovanni under conductor Plácido Domingo.
[15][16] Also in 2014, she made her debut at the San Francisco Opera as Amelia in Un ballo in maschera, appeared at the Hollywood Bowl as Nedda in Pagliacci with the Los Angeles Philharmonic, and portrayed Desdemona in Otello at the Teatro Massimo.