The singer starred in Kahit Nasaan Ka Man in 2013, My Guitar Princess in 2018, and Heartful Café in 2021 under GMA Network.

She won acting credits with ensemble soaps such as Buena Familia in 2015–2016 and a remake of the film Pinulot Ka Lang sa Lupa in 2017.

San Jose did not pursue a full-time show business career until 2005 when she joined Pop Star Kids, a singing competition on QTV (now GTV) hosted by R&B singer-songwriter Kyla.

The group had a show on QTV titled Planet Q, where a young San Jose and her groupmates showcased their hosting abilities.

[9] She did various soundtracks for Kapuso teleseryes and shows including two for Marian Rivera's Dyesebel: Aking Mundo and Siya Na Nga Kaya.

[10] In November 2008, she sang the GMA Christmas Station ID, "Awit ng Puso", composed by Simon Peter Tan.

[11] In 2008, San Jose made her acting debut on GMA Network's afternoon soap opera Gaano Kadalas and Minsan?, where she played a supporting character to Camille Prats and Marvin Agustin.

[17] Archuleta revealed in an interview that it was his personal choice to have Julie Anne San Jose as the front act for his concert.

[18] Six months later, she released her eponymous debut album, Julie Anne San Jose, which received numerous awards and was certified Diamond Record awardee.

She played the role of Antoinette Escueta, more popularly known as Toyang, a boyish daddy's girl who falls in love with her best friend.

She played the role of Maria Bettina "Beto" Reyes Salazar and sang the movie theme song "Bakit Ba Ganyan?"

Guests included the dance crew Addlib, Fliptop star Abra, Elmo Magalona, and Frencheska Farr, a multi-faceted performer and friend of San Jose.

She played the lead role in the primetime drama series Kahit Nasaan Ka Man, a visually impaired but musically talented girl named Pauline Gomez.

[26] In 2015, San Jose released her digital single "Tidal Wave," which was arranged by Sidney Brown, better known as Omen, an American music producer from Harlem.

San Jose filmed three music videos in New York City and California with Los Angeles-based company VIM Entertainment.

[27][28] In October 2015, Julie Anne San Jose, was chosen alongside Christian Bautista to represent the Philippines in the One-Asia Seoul Mega Concert in South Korea.

San Jose was part of the afternoon soap Buena Familia alongside Kylie Padilla, Julian Trono, and Jake Vargas, who is her current on-screen partner.

[43] In January 2017, she played the lead role in the afternoon soap Pinulot Ka Lang sa Lupa as Santina Marquez.

[44] In June 2017, San Jose went viral online with her cover of the latest hit single "Despacito" by Luis Fonsi featuring Daddy Yankee and Justin Bieber.

[45] The Viral YouTube Video Cover also landed a feature on famous international sites like 9gag TV and Superstar Magazine.

[51] In May 2018, as Cosmopolitan magazine Philippines marked their last print issue, Julie Anne San Jose was featured on the final cover.

Breakthrough also received impressive sales during the jam-packed Grand Album Launch at the Eastwood Mall Open Park.

[53][54] In November 2018, she was invited on Gary Valenciano's Advocacy Album, Awit at Laro, to promote Filipino games and songs through art and music.

She is the only GMA Artist on the album, in which San Jose performs the song "Pitik Bulag", Composed by Jungee Marcelo.

[55] In May 2018, San Jose starred in a daytime musical series My Guitar Princess, where she plays the main character, Celina Raymundo, a.k.a.

Minutes after its release, the single reached the top spot on the iTunes Philippines All Genre and Pop Charts, continuing her streak of No.

[72] San Jose is also a celebrity advocate of World Vision, an international child-focused non-government organization that mainly promotes children's rights, well-being, and education.

[74] Rayver Cruz and San Jose began dating in February 2022 as they also exchanged "I love you's" on November 26, 2023 at the Newport Performing Arts Theater.